Breakdown of classical paradigms in relation to membrane structure and functions

Updates of the mosaic fluid membrane model implicitly sustain paradigms that bilayers are closed systems conserving a state fluidity and behaving as dielectric slab. All them consequence disregarding water part structure its essential role in thermodynamics kinetics response to bioeffectors. A correlation thermodynamic properties with structural features makes possible introduce lipid responsive due relaxation rearrangements bioeffectors' interactions. This analysis concludes membranes open and, according irreversible formalism, monolayers can be reasonable compared under controlled conditions. The inclusion complex feasible reconsider concept slab fluidity. • Membrane system includes water. Bilayers equivalent grounds. is material. derives from rearrangement organization.